Serious, life-threatening side effects can occur if you take Promethazine with DM before the MAO inhibitor has cleared from your body. It blocks the effects of the naturally occurring chemical histamine in your body. Children should be supervised to avoid potential harm in bike riding or in other hazardous activities. Dextromethorphan: Hyperpyrexia, hypotension, and death have been reported coincident with the coadministration of monoamine oxidase (MAO) inhibitors and products containing dextromethorphan. Why You Should Rethink That Drink Before Dinner, New Clues Why Mosquitoes Find You Irresistible, Popular Heartburn Meds Can Have Health Risks. A WIDE RANGE OF WEIGHT-BASED DOSES OF PROMETHAZINE HYDROCHLORIDE HAVE RESULTED IN RESPIRATORY DEPRESSION IN THESE PATIENTS. PROMETHAZINE HYDROCHLORIDE AND DEXTROMETHORPHAN HYDROBROMIDE ORAL SOLUTION- promethazine hydrochloride and dextromethorphan hydrobromide oral solution solution  Children should be supervised to avoid potential harm in bike riding or in other hazardous activities. I stopped the cough syrup since ive taken half the bottle of this and an entire rx of something simular to Otc robitussin dm which was better. However, it may have undesirable effects on a nursing infant. Dextromethorphan hydrobromide occurs as white crystals sparingly soluble in water and freely soluble in alcohol. THE EXTRAPYRAMIDAL SYMPTOMS WHICH CAN OCCUR SECONDARY TO PROMETHAZINE HYDROCHLORIDE ADMINISTRATION MAY BE CONFUSED WITH THE CNS SIGNS OF UNDIAGNOSED PRIMARY DISEASE, e.g., ENCEPHALOPATHY OR REYE'S SYNDROME. For Cough: “Did not help my cough at all. Glucose Tolerance Test: An increase in blood glucose has been reported in patients receiving promethazine. If you are using any of these drugs, you may not be able to use Promethazine with DM, or you may need dosage adjustments or special tests during treatment. It can increase some of the side effects of dextromethorphan and promethazine. Avoid drinking alcohol. Read expert perspectives on popular health topics. Promethazine was nonmutagenic in the Salmonella test system of Ames. Promethazine-DM syrup should only be prescribed to relieve the symptoms of upper respiratory infections. severe dizziness, anxiety, restless feeling, or nervousness; hallucinations (seeing or hearing things); nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or. Very high doses may produce respiratory depression. During pregnancy, this medication should be used only if clearly needed. the pharmacy said this was not the best medicine for my symptons. Dextromethorphan is metabolized primarily by liver enzymes undergoing O-demethylation, N-demethylation, and partial conjugation with glucuronic acid and sulfate.

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